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Efficacy and safety of lixisenatide once-daily versus exenatide twice-daily in patients with type 2 diabetes insufficiently controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X) // Diabetes Care

The GLP-1 hormone prompts the pancreas to produce more insulin, which lowers blood sugar levels, while inhibiting the production of glucagon, which raises blood sugar levels

This energy deficit, while promoting weight loss, can result in fatigue, lightheadedness, and generalized weakness, particularly during the initial weeks of treatment or after dose escalation